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The ligands were bound to D106 according to the crystal structures using the [intermolecular_interactions] block of GROMACS with a bond length of 0.185 nm, a force constant of 10 5 kJ mol 1 nm 2 and bond type 6

A growing body of evidence implicates the kynurenine (KYN) pathway (KP) in the pathophysiology of MDD [17, 18]

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It acts as a master antioxidant, cycling between reduced and oxidized states to neutralize free radicals and reactive intermediates